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Annual Document

Annual Document according German Securities Prospectus Act, s. 10

Fiscal year 2010/2011

Pursuant to section 10 of the German Securities Prospectus Act (WpPG), which entered into force on July 1, 2005, listed companies are obliged to make annually available to the public a document containing information published or made available to the public within the preceding twelve months in order to comply with certain regulations under German corporate and capital market law (“Annual Document”).

Please note that the information contained or referred to in this Annual Document pursuant to section 10 WpPG is not updated and can therefore be out of date. Neither the Annual Document nor the information contained therein or information to which the Annual Document refers to constitute an offer or a request to make an offer to acquire or sell securities.

From April 1, 2010 up to and including March 31, 2011 SYGNIS Pharma AG published or made available to the public the following information pursuant to section 10 para. 1 WpPG:

Financial Reports

Ad Hoc Releases according to § 15 WpHG

Financial Schedule

Preliminary Announcement on the Disclosure of Financial Statements

Annual Shareholder’S Meeting

Reporting

Corporate News

Director’s Dealings according to section 15a WpHG

Report on voting rights



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